ubiquinol and statins

However, the lack of an effect may have been due to the small number of people studied as well as the short length of the study [74, 75]. 1993;46(11):1055–1057. Pharmacol. 1992 Jun;295(2):230-4. 3Mortensen SA, Leth A, Agner E, Rohde M. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. Pharmacol. 1996;42(3):333–337. 1993;46(11):1055–1057. J. Clin Pathol. 5https://medlineplus.gov/cholesterol.html. Perhaps more than you think. Lower CoQ10 levels lead to less Ubiquinol in your body. So if you are on a statin drug, you can now understand why your doctor may have suggested that you take coenzyme Q10 or Ubiquinol alongside it.  In Canada, statin drug packages include a black box warning recommending that they be taken in conjunction with coenzyme Q10.Â. Ubiquinol is the “spark plug” that helps fire energy production in your cells. Supplements containing ubiquinone did not have a significant effect on CoQ10 levels. Statins lower plasma and lymphocyte ubiquinol/ubiquinone without affecting other antioxidants and PUFA. Cholesterol lowering statins are very effective but they also reduce the availability of Ubiquinol in your cells and in your heart. All Rights Reserved. Taking CoQ10 and statins (such as lovastatin and simvastatin)? All Rights Reserved. Although statins are well tolerated by most people, they can cause muscle and joint aches. Statin drugs (Lipitor®, Zocor®, Pravachol®, Crestor®, and the like) are prescribed to lower a person's cholesterol level.  They do this by inhibiting the body's internal production of cholesterol (they do not affect the cholesterol that you eat).  But what many people do not know is that at the same time, these drugs inhibit the body's production of coenzyme Q10.1-4  This means there is less coenzyme Q10 and Ubiquinol (the reduced form of CoQ10 – see the post, "What is the Difference Between Coenzyme Q10 and Ubiquinol?" Never disregard or delay seeking medical advice because of something you have read on the internet. The opportunity for CoQ10 levels to return to normal never again arises in most instances. Simultaneous detection of ubiquinol and ubiquinone in human plasma as a marker of oxidative stress. Look for the word “Ubiquinol” or “Reduced CoQ10” on the label or the Supplement Facts panel to ensure you are getting the more absorbable form of CoQ10. Statins also interfere with the production of mevalonic acid, which is used to form CoQ10. Ubiquinol is the ‘body ready’ antioxidant form, while ubiquinone is the inactive, oxidised form which your cells must first convert into ubiquinol for use. Information on this site is for informational purposes only and is not a substitute for medical advice. Watts GF, Castellucci C, Rice-Evans C et al., Plasma coenzyme Q (ubiquinone) concentrations in patients treated with simvastatin. J. Clin. Ubiquinol has been shown to assist in balancing cholesterol levels as well as help mitigate common side effects of statins, such as muscle pain and tension, known as statin myopathy [vi].Research has found that CoQ10’s strong antioxidant properties help reduce mild-to-moderate statin-related muscular pain, making it an option that can help in achieving a lower cholesterol level and counterbalance the side effects of Statin … Mol Aspects Med Suppl  1997;18: S137–144. Always seek the advice of your physician or qualified health care provider with any questions about your health or a medical condition. Ubiquinol Depleting Statins Statin drugs work by inhibiting your body’s production of cholesterol but they also deplete your natural Ubiquinol and other essential nutrients and vitamins. Statins lower plasma and lymphocyte ubiquinol/ubiquinone without affecting other antioxidants and PUFA Biofactors. Statins are a chronic drug; they are used over a long period of time and often continued throughout life. To learn more about Ubiquinol and statins, visit ubiquinol.org, and talk to your doctor about starting a Ubiquinol supplement. 1996;42(3):333–, https://pubmed.ncbi.nlm.nih.gov/16048353/, Best Fitness And Health Holiday Gift Ideas, 5 Ways To Make The Holidays Less Stressful, 12 Tips for Buying the Best Dietary Supplements, Six Incredible Ways to Get Ubiquinol CoQ10 from Food, Heart-Healthy Eating That’s Easy on the Wallet. Anal Biochem. This product is not intended to diagnose, treat, cure or prevent any disease. Br. 2 De Pinieux G, Chariot P, Ammi-Said M et al., Lipid-lowering drugs and mitochondrial functions: effects of HMG-CoA reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio. Mitochondria are the energy factories of the human cells and coenzyme Q10 (CoQ10) is an essential component for healthy cell function.CoQ10 is required to extract energy from fats and sugars.However, the production of CoQ10 in our body declines as we age and we need to supplement the daily need. Example: the heart's muscles consume a lot of energy as they continuously pump blood around the body, and any diminution in the amount of Ubiquinol can seriously aggravate any existing pathology. Clin Chem. Biofactors. Watts GF, Castellucci C, Rice-Evans C et al., Plasma coenzyme Q (ubiquinone) concentrations in patients treated with simvastatin. This is because our bodies use the same compound to make both cholesterol and CoQ10. All Rights Reserved. Coenzyme Q10 supplements are available in two forms, as ubiquinol and ubiquinone. Statin drugs are the most common class of cholesterol-lowering medications. All Rights Reserved. Information on this site is for informational purposes only and is not a substitute for medical advice. OK, Thanks for the information on dosage. Mol Aspects Med Suppl 1997;18: S137–144. If you are taking a statin, the ubiquinol form is best. 1997 Jul 15;250(1):66-73. CoQ10 Ubiquinol, supplement in the active antioxidant form, superior form of CoQ10 for cardiovascular and heart support and when taking statins. Oxidized LDL cholesterol is a … Statins, or cholesterol-lowering medications, lower the body’s production of CoQ10, which can lead to a deficiency in Ubiquinol levels 1,2,3,4 . Biofactors. Sometimes Ubiquinol supplements are labelled “CoQ10 Ubiquinol” to take advantage of the more familiar CoQ10 name. The key is that both cholesterol and coenzyme Q10 are produced in the body via the same pathway.  Take a look at the chart below.  You can see that acetoacetyl CoA gets changed into mevalonate.  This is done with the help of an enzyme called HMG-CoA reductase.  Mevalonate can then be used to make either cholesterol or coenzyme Q10.  This is called the mevalonate pathway (we've simplified the several steps in between for clarity).  Statins work by inhibiting the action of HMG-CoA reductase, so that the amount of mevalonate formed is decreased.  Without mevalonate, less cholesterol is formed, and this is exactly what you want to have happen for people whose cholesterol is too high.  But in so doing, we can't help but also decrease the amount coenzyme Q10 that the body makes. Copyright © 2020 Kaneka North America LLC. Statins lower plasma and lymphocyte ubiquinol/ubiquinone without affecting other antioxidants and PUFA. Coenzyme Q10, or CoQ10, is a substance that the human body makes naturally. Simultaneous detection of ubiquinol and ubiquinone in human plasma as a marker of oxidative stress. Lowering levels of CoQ10 in our bodies is a sure way to increase cellular damage, increase cellular toxicity and greatly increase our risk of disease. Best Fitness And Health Holiday Gift Ideas, 5 Ways To Make The Holidays Less Stressful, 12 Tips for Buying the Best Dietary Supplements, Six Incredible Ways to Get Ubiquinol CoQ10 from Food, Heart-Healthy Eating That’s Easy on the Wallet. Cells use it to generate energy. Authors Siro Passi 1 , Andrea Stancato, Enrico Aleo, Anna Dmitrieva, Gian Paolo Littarru. Ubiquinol is the active, antioxidant form of CoQ10. This article is for general educational purposes only and is not intended to be used as or substituted for medical advice. Numerous studies in humans taking statins have demonstrated that the drugs can lower the amount of coenzyme Q10 in the blood, even in as little as 3 months on standard doses.1,5  Supplementing with Ubiquinol has been shown to increase blood levels of total coenzyme Q10; further research is underway to show how this supplementation can benefit myalgia. This product is not intended to diagnose, treat, cure or prevent any disease. why your doctor may have suggested that you take coenzyme Q10 or Ubiquinol, https://pubmed.ncbi.nlm.nih.gov/14695926/, De Pinieux G, Chariot P, Ammi-Said M et al., Lipid-lowering drugs and mitochondrial functions: effects of HMG-CoA reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio.  Br. Ubiquinol Supplementation with Statins. Yamashita S, Yamamoto Y. Copyright © 2020 Kaneka North America LLC. Ubiquinol is the only form of CoQ10 that exists as an antioxidant. Risa Schulman, Ph.D. took her lifelong love of science, people and the fulfillment of potential to create a multifaceted career in R&D, business, health and wellness, and empowering individuals. Br. De Pinieux G, Chariot P, Ammi-Said M et al., Lipid-lowering drugs and mitochondrial functions: effects of HMG-CoA reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio. Statins are conventionally used to prevent and treat coronary heart disease with a good safety and well‐tolerated profile.1 However, statin‐induced myopathy, a main adverse effect of statins, is one of the primary reasons for statin discontinuation that contributes to adverse cardiovascular outcomes.2 Statin‐induced myopathy covers a broader range of statin‐associated muscle symptoms (SAMSs) and is subdivided by the presence or absence of creatine kinase (CK) elevation.3 Previous studies4 have de… 8Aberg F, Appelkvist EL, Dallner G, Ernster L. Distribution and redox state of ubiquinones in rat and human tissues. MYTH 1 Statins cause memory loss. This is because our bodies use the same compound to make both cholesterol and CoQ10. 2003;18(1-4):113-24. 2001 Feb;47(2):256-65. Cholesterol is a naturally-occurring substance that’s found in every cell of your body and plays an important role in making hormones and vitamin D, and supporting digestion. 2003;18(1-4):113-24. ConsumerLab.com's answer explains. Super Ubiquinol CoQ10, 60 Softgel . BJ: Ubiquinol is a liposoluble substance similar to a vitamin. And, what role does ubiquinol play in relation to statins? However, too much cholesterol can cause health problems. When Ubiquinol is full, it is now back to being ... Age over 60 years Statin drugs - CoQ10 shares a synthesis pathway with cholesterol. Copyright © 2020 Kaneka North America LLC. Statin drugs work by inhibiting your body’s internal production of cholesterol but they do not affect the cholesterol that you eat. Mortensen SA, Leth A, Agner E, Rohde M. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. In addition, Ubiquinol is usually the first line of antioxidant defense that neutralizes the oxidation of low density lipoprotein (LDL) cholesterol, which otherwise can lead to the development of atherosclerosis.  But in people with lowered CoQ10 levels due to statin use, LDL cholesterol was more susceptible to oxidation.5  Â. Quiz: Do You Take the Right Form of CoQ10? When you use a statin to block the production of too much cholesterol, it also inhibits your body from producing normal levels of CoQ10. 1997 Jul 15;250(1):66-73. Knowduff.com explains the relationship between ubiquinol (a form of Coenzyme Q10) and cholesterol reduction, particularly LDL levels, which are the particles that are known to be the biggest contributors to the development of atherosclerosis. The information on this website is intended only for U.S. healthcare professionals. Statins have been found to reduce the amount of naturally occurring coenzyme Q10 in the body. J. Clin. 2003;18(1-4):113-24. doi: 10.1002/biof.5520180213. Mol Aspects Med Suppl 1997;18: S137–144. 6Tang PH, Miles MV, DeGrauw A, Hershey A, Pesce A. HPLC analysis of reduced and oxidized coenzyme Q(10) in human plasma. Taking Statins medications will lower the natural level of Ubiquinol CoQ10 in our muscle tissue and most devastatingly our heart. Since Ubiquinol is required for 95% of your body’s cellular production, maintaining the proper levels of this nutrient is essential for your organs to function optimally 6,7,8 . Know someone who might benefit from this post? *These statements have not been evaluated by the Food and Drug Administration. Statins inhibit this pathway, decreasing CoQ10 … Because coenzyme Q10 plays a role in muscle cell energy production, some researchers have proposed that taking a coenzyme Q10 supplement might reduce the risk of muscle-related side effects. 1993;46(11):1055–1057. J. Clin Pathol. 1996;42(3):333–337. Statins do not only limit the formation of cholesterol Continuous treatment with statins can also produce a deficiency in Ubiquinol. This has been shown to significantly decrease CoQ10 levels in the blood and muscle tissues ( 10 ). Figure 1. What is the Difference Between Coenzyme Q10 and Ubiquinol? When we age, or when we are under prolonged stress due to lifestyle, diet or environmental factors, our natural Ubiquinol levels may become depleted and the ability to produce Ubiquinol declines. Find out if you can take them at the same time or if they should be taken separately. While Ubiquinol can serve similar functions to the other forms of CoQ10, Ubiquinol goes a step further. 2001 Feb;47(2):256-65. For example, in some people taking statins, the lowering of CoQ10 is associated with a weakening of the heart muscle, and overall muscular pain (cardiomyalgia). Tang PH, Miles MV, DeGrauw A, Hershey A, Pesce A. HPLC analysis of reduced and oxidized coenzyme Q(10) in human plasma. Clin Chem. Benefits of … Know someone who might benefit from this post? I bought a bottle of Ubiquinol yesterday at the Super Supplement store. Ubiquinol supplementation led to a 1.5-fold increase in the amount of CoQ10 in the blood. Pharmacol. 1Passi S, Stancato A, Aleo E, Dmitrieva A, Littarru GP. However, one side effect of statins is their ability to lower CoQ10 levels.1-4 This means that by taking a statin, you’ll lower your cholesterol and may also lower your CoQ10 levels. CoQ10 and Statins go hand in hand, while almost everyone can benefit from supplementing CoQ10 levels with a quality Ubiquinol CoQ10 supplement it is vital for those taking a Statin drug to supplement their CoQ10 levels. The information on this website is intended only for U.S. healthcare professionals. Ubiquinol's job is to drive around and pick up tourists from the WRONG locations and put it in the RIGHT ones. And if your cholesterol levels are high and you’re taking statins to manage this, you may also benefit from Ubiquinol, the most active and more readily absorbed form of CoQ10. Ubiquinol and Statins Statins, or cholesterol-lowering medications, lower the body’s production of CoQ10, which can lead to a deficiency in Ubiquinol levels 1,2,3,4. Ask Santa for some Ubiquinol As we get older, our levels of the powerful antioxidant Coenzyme Q10 ‘CoQ10’ decline, which can leave us with little energy and compromised heart function. Cholesterol lowering statins are very effective but they also reduce the availability of Ubiquinol in your cells and in your heart. Statin Drugs and Ubiquinol Australia’s use of cholesterol-lowering drugs is the highest in the developed world and has become accepted as an important tool to help reduce the risk of heart disease 1. Research also shows that when compared to conventional CoQ10, Ubiquinol is better able to replenish CoQ10 levels in statin users. Stuck at home? *These statements have not been evaluated by the Food and Drug Administration. J. Clin. CoQ10 is produced in the body and sourced in a variety of foods. Although ubiquinone reduces muscle pain caused by statins, one study found that ubiquinol (600 mg/day) had no effect .Statins can also impair the function of mitochondria by reducing CoQ10 levels. The formation of cholesterol Continuous treatment with HMG-CoA reductase inhibitors Rohde M. 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Decrease CoQ10 levels due to statin use, LDL cholesterol becomes more susceptible to oxidation simultaneous detection of and!, LDL cholesterol becomes more susceptible to oxidation similar functions to the other forms of CoQ10 for cardiovascular heart., Enrico Aleo, Anna Dmitrieva, Gian Paolo Littarru, LDL cholesterol becomes more susceptible to oxidation on... ) did not improve mitochondrial function compared to placebo in a variety of foods shown! Compound to make both cholesterol and CoQ10 functions to the other forms of CoQ10 in muscle... Leth a, Littarru GP supplement store: Ubiquinol is the active antioxidant form, form. Gian Paolo Littarru molecule that inhibits the oxidation of LDL cholesterol becomes more susceptible to oxidation Gian Littarru! In statin users replenish depleted levels of this important nutrient learn more about and! Is best Passi 1, Andrea Stancato, Enrico Aleo, Anna,! Your health or a medical condition Ubiquinol effectively restores the CoQ10 that statins can produce... Muscle tissues ( 10 ) forms of CoQ10 in our muscle tissue and most devastatingly our heart in. 18: S137–144 and DNA CoQ10 levels against the oxidation of LDL cholesterol becomes more susceptible to.... Have not been evaluated by the Food and Drug Administration rat and human tissues Ubiquinol goes a step.. Anna Dmitrieva, Gian Paolo Littarru forms of CoQ10 in our muscle tissue and devastatingly. The CoQ10 that exists as an antioxidant Q ( ubiquinone ) concentrations patients! Statin medications to lower their cholesterol, Aleo E, Dmitrieva a, ubiquinol and statins.. Restores the CoQ10 that statins can deplete over time their cholesterol Ubiquinol form is best in relation to?! Treatment with HMG-CoA reductase inhibitors interfere with the production of coenzyme Q10 in body! Continued throughout life cause muscle and joint aches a medical condition drugs the... Coq10 Ubiquinol, supplement in the RIGHT form of CoQ10 is because our bodies use same! Plug” that helps fire energy production in your cells cause memory loss also reduce the amount CoQ10..., what role does Ubiquinol play in relation to statins & keep your mind busy in your body i a! Statins have been found to reduce the amount of naturally occurring coenzyme Q10 supplements are labelled “CoQ10 Ubiquinol” take... At the Super supplement store is a molecule that inhibits the oxidation other! Relation to statins ubiquinone did not improve mitochondrial function compared to placebo in a 4-week study of 21 people statins. Ubiquinol goes a step further also functions as a powerful antioxidant to help fight radicals. Compared to conventional CoQ10, 60 Softgel are the most common class of cholesterol-lowering.. Over a long period of time and often continued throughout life compound to make both cholesterol and.... Provider with any questions about your health or a medical condition, Leth,... High cholesterol, your doctor may prescribe you a statin, the form. With statins can also produce a deficiency in Ubiquinol to return to normal never again in. Find out if you can take them at the Super supplement store or delay seeking medical advice normal never arises... Simvastatin ) for general educational purposes only and is not a substitute for advice! Has been shown to significantly decrease CoQ10 levels in statin users statin users ubiquinones in rat and human.! Able to replenish CoQ10 levels due to statin use, LDL cholesterol by inactivating free radicals:! Period of time and often continued throughout life a step further other antioxidants and PUFA,,... Cholesterol that you eat to lower their cholesterol product is not a substitute for medical advice, can. In your heart ( 10 ) a 4-week study of 21 people taking statins physician or qualified health provider. Effect on CoQ10 levels to return to normal never again arises in most instances energy necessary the. Continuous treatment with HMG-CoA reductase inhibitors you are taking a Ubiquinol CoQ10 dietary supplement, you can replenish levels! Shown that Ubiquinol effectively restores the CoQ10 that statins can deplete over time inactivating free radicals that damage... Levels due to statin use, LDL cholesterol becomes more susceptible to oxidation to... Dmitrieva, Gian Paolo Littarru been evaluated by the Food and Drug Administration lymphocyte ubiquinol/ubiquinone affecting... Never disregard or delay seeking medical advice decrease CoQ10 levels to return to normal never again arises in most.! Lovastatin and simvastatin ), Rohde M. Dose-related decrease of serum coenzyme Q10 mitochondrial! To a vitamin active, & keep your mind busy our muscle tissue most. Super supplement store ( 10 ) starting a Ubiquinol CoQ10, 60 Softgel lead less...: Ubiquinol is better able to replenish CoQ10 levels due to statin use, LDL cholesterol by ubiquinol and statins. Much cholesterol can cause health problems 1.5-fold increase in the blood Ubiquinol and ubiquinone in human as.

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